Please read Dr. Gould’s article in Biological Psychiatry: Global Open Science titled, “Perineuronal Nets in the Dorsomedial Striatum Contribute to Behavioral Dysfunction in Mouse Models of Excessive Repetitive Behavior.“
Maladaptive repetitive behavior is a common symptom of several neuropsychiatric disorders, including autism spectrum disorder, schizophrenia, obsessive-compulsive disorder, and other anxiety-related psychopathologies. These symptoms impair everyday living throughout the lifespan and likely increase the severity of other symptoms, such as impaired cognition and social deficits. In humans, studies have linked repetitive and inflexible behaviors with corticostriatal circuits, where impairments in modulatory function are hypothesized to exacerbate symptom severity. Rodent dorsal striatum dysfunction has been linked to aberrant repetitive behaviors, including self-injurious overgrooming and excessive digging. To read the full article.
Perineuronal Nets in the Dorsomedial Striatum Contribute to Behavioral Dysfunction in Mouse Models of Excessive Repetitive Behavior. Briones BA, Pitcher MN, Fleming WT, Libby A, Diethorn EJ, Haye AE, MacDowell CJ, Zych AD, Waters RC, Buschman TJ, Witten IB, Gould E. Biol Psychiatry Glob Open Sci. 2021 Nov 17;2(4):460-469. PMID: 36324654 PMCID: PMC9616293 DOI: 1016/j.bpsgos.2021.11.005