Please read Dr. Cohen’s article in Biosensors and Bioelectronics titled, “Come together: On-chip bioelectric wound closure.“
There is a growing interest in bioelectric wound treatment and electrotaxis, the process by which cells detect an electric field and orient their migration along its direction, has emerged as a potential cornerstone of the endogenous wound healing response. Despite recognition of the importance of electrotaxis in wound healing, no experimental demonstration to date has shown that the actual closing of a wound can be accelerated solely by the electrotaxis response itself, and in vivo systems are too complex to resolve cell migration from other healing stages such as proliferation and inflammation. This uncertainty has led to a lack of standardization between stimulation methods, model systems, and electrode technology required for device development. In this paper, we present a ‘healing-on-chip’ approach that is a standardized, low-cost, model for investigating electrically accelerated wound healing. To read the full article.
Come together: On-chip bioelectric wound closure. Zajdel TJ, Shim G, Cohen DJ. Biosens Bioelectron. 2021 Nov 15;192:113479. PMID: 34265520 PMCID: PMC8453109 DOI: 1016/j.bios.2021.113479 Epub 2021 Jul 8