Please read Dr. Aleksunes’ article in Toxicology Letters titled, “High-throughput screening of toxicants that modulate extravillous trophoblast migration.”
The human placenta is a unique organ that while temporary has a lasting effect on fetal development. A major step in proper formation of the placenta is the migration and invasion of extravillous trophoblasts (EVT) into the maternal decidua and remodeling of spiral arteries. During this process, arteries transition from high resistance to low resistance leading to efficient exchange of nutrients, waste, solutes, and oxygen at the maternal-fetal interface. Aberrations in trophoblast migration have been associated with a variety of gestational outcomes including preeclampsia, eclampsia, placenta accreta spectrum, fetal growth restriction, and more. Therefore, it is essential to understand how perturbations to these processes mediate adverse gestational outcomes. To read the full article.
High-throughput screening of toxicants that modulate extravillous trophoblast migration. Cassandra Meakin, Christine Kim, Thomas Lampert, Lauren M Aleksunes. Toxixol Lett. 2023 Feb 15;375:1-7. PMID: 36535517 PMCID: PMC9877196 DOI: 10.1016/j.toxlet.2022.12.004