Please read Dr. Barker’s article in Genes, Brain and Behavior titled, “Neuropathic pain as a trigger for histone modifications in limbic circuitry.”
Chronic pain is a disorder characterized by persistent nociceptive hypersensitivity, often accompanied by allodynia (pain elicited by non‐painful stimuli), and hyperalgesia (an amplified response to painful stimuli). According to the CDC, an estimated 20.4% of the adult population in the United States experienced chronic pain in 2019, and 7.4% of adults were categorized as having high impact chronic pain that limited their lifestyle and work abilities. The limitations of the current therapeutics emphasize the need for more effective, safe treatment strategy for chronic pain and a better understanding of its underlying mechanisms. To read the full article.
Neuropathic pain as a trigger for histone modifications in limbic circuitry. S. Bryant, J. Balouek, L. Geiger, D. Barker, C. Pena. Genes Brain Behav. 2023 Feb;22(1):e12830. doi: 10.1111/gbb.12830. Epub 2022 Nov 22. PMID: 36412100; PMCID: PMC9994138.