Please read Drs. Jude. Xu, and Panettieri’s article in Molecular Aspects of Medicine titled, “Metabolomics in asthma: A platform for discovery.“
Metabolome identifies the global collection of small molecules generated from cellular metabolic processes. Technically, metabolomics and metabonomics are used interchangeably. Metabolomics analyzes and defines the entire metabolome in organisms and multicellular systems, while metabonomics describes the metabolic changes in the system often in response to an evoked phenotype or interventions. Compared to other “omics” approaches measuring global cellular changes, metabolomics characterizes the dynamic changes of small molecules generated from a multitude of complex intracellular processes. In fact, the metabolomic profile of a cell represents the downstream output of the transcriptomic and proteomic changes and the upstream input to the phenotype. Therefore, metabolomic profile encompasses information captured in transcriptomic and proteomic profiles of the cell. To read the full article.
Metabolomics in asthma: A platform for discovery. Xu S, Panettieri RA Jr, Jude J. Mol Aspects Med. 2022 Jun;85:100990. doi: 10.1016/j.mam.2021.100990. PMID: 34281719 DOI: 1016/j.mam.2021.100990 Epub 2021 Jul 17.