Please read Dr. Aleksunes’ article in the Journal of Hazardous Materials titled, “Hybrid non-animal modeling: A mechanistic approach to predict chemical hepatotoxicity.“
Hepatotoxicity, often referred to as drug-induced liver injury (DILI), is a leading cause of acute liver failure in the United States and Europe and the primary reason for drug attrition during development. The idiosyncratic metabolic nature of DILI continues to prompt the cessation of clinical trials and even the recall of drugs post-marketing. Given the severity and potential for DILI to hinder drug development, risk assessments are essential to mitigate potential life-threatening adverse reactions to drugs, environmental agents, and other xenobiotics. As the pathogenesis of DILI is one of the most complex toxicity phenomena, there are currently no applicable alternative models available for its assessment. DILI involves numerous cellular and biochemical processes, and many compounds that induce hepatotoxicity have poorly understood mechanisms. Given the concern for hepatotoxicity across diverse areas of toxicology, comprehensive assessments are imperative. To read the full article.
Hybrid non-animal modeling: A mechanistic approach to predict chemical hepatotoxicity. Chung E, Wen X, Jia X, Ciallella HL, Aleksunes LM, Zhu H. J Hazard Mater. 2024 Jun 5;471:134297. PMID:38677119 DOI: 1016/j.jhazmat.2024.134297