Understanding polygenic risk from the lens of a learning healthcare system presented by Chris Gignoux, Ph.D., Associate Professor Interdisciplinary Quantitative Biology, University of Colorado Boulder.
The wealth of insights from genome-wide association studies has led to increased interest in the potential clinical applications of polygenic risk scores. Here, biobanks provide a novel opportunity to examine polygenic effects in real-world healthcare settings and to investigate across hundreds to thousands of traits. In this paper, I will describe the development of the Colorado Center for Personalized Medicine, a large institutional biobank with a robust and scalable return-of-results program. I will then discuss how we have utilized this new resource to study the potential, as well as the pitfalls, of polygenic scoring, particularly across the spectrum of human genetic diversity.
Noon, Monday, December 18, 2023
Life Sciences Building | Auditorium | 145 Bevier Road, Piscataway
Zoom Meeting Registration | Meeting ID: 935 7436 1552 | Passcode: 532445
Host: Tara Matise | Ph: 848-445-3125 | Email: matise@rutgers.edu